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(a) On-line troubleshooting via a searchable Knowledgebase, answers to frequently asked questions, the latest driver and firmware downloads, and email support at www.cusa.canon.com/support. (b) Toll free telephone support at 1-800-OK-CANON (652-2666), Monday through Friday from 8:00 a.m. to 8:00 p.m. Eastern Time (excluding holidays).
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For the secondary analyses, when comparing the non-hospitalised cases with the controls (Model 2), the same general pattern emerged, albeit with a reduced number of significant results: one olfactory-related region, the functionally connected areas to the temporal piriform cortex, showed a significant longitudinal difference between the two groups in a diffusion index, as well as one global volume measure (CSF normalised), and a diffusion index in the superior fronto-occipital fasciculus (Model 2; 4 after FDR correction, 1 after FWE correction; Supplementary Table 1). Despite the considerably limited degrees of freedom in Models 3 and 4, many results remained significant after correction for multiple comparison, particularly for IDPs of cortical thickness, with an emphasis on the anterior cingulate cortex for Model 3 (66 results after FDR correction, 3 results after FWE correction), and a wide distribution across prefrontal, parietal and temporal lobes for Model 4 (29 FDR-corrected results; Fig. 2).
As part of the UK Biobank imaging study60, thousands of participants had received brain scans before the start of the COVID-19 pandemic. Multimodal brain imaging data, collected at four sites with identical imaging hardware, scanner software, and protocols, and passing quality controls, were obtained from 42,729 participants over the age of 45 years, and made available to researchers worldwide.
The case-versus-control difference in this longitudinal IDP effect was modelled with a group difference regressor comprising the case-versus-control binary variable modulated by a function of age at scan 2 (Age2, a close proxy for age at infection for the SARS-CoV-2 group, with an error of less than a year). We chose to focus on an objective age model given the strong prior knowledge of a highly increased detrimental effect, at older ages, of SARS-CoV-2 infection and a greater vulnerability of the brain with age. The age dependence has been found to be exponential in studies of the effects of COVID-19 on hospitalisation and fatality rate75,76. Here we used the exact age dependence found by a data-driven meta-regression of 28 studies, with no free or subjectively chosen parameters, to modulate the binary case-versus-control variable, based on age at scan 2 (ref. 76). 2ff7e9595c
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